On January 5, 2010, Silence Therapeutics completed its merger with Intradigm. A new website for the merged company is under development. In the meantime, please visit www.silence-therapeutics.com.

THERAPEUTIC PLATFORM

Sequence Library

The ability to effectively select appropriate disease targets plays a critical role in the development and optimization of RNAi therapeutics.

KEY SEQUENCE FEATURES
  • Double Blunted-Ended
  • High Potency
  • 25 Base-Pairs in Length  
  • Optimized Molecular Structure
  • Cross-Species Homology
          

To maximize target selection success, Intradigm weighs a number of critical considerations including the role the target plays in disease modification, the cell type in which the target is expressed, and the potential freedom to operate in developing a therapeutic against the target. Through diligent scientific research based on bioinformatics algorithms and unique know-how, Intradigm has compiled a library of proprietary siRNA sequences against more than 50 high-value disease targets.